2-Fluoroamphetamine

Stimulant designer drug From Wikipedia, the free encyclopedia

2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug.[1] 2-Fluoroamphetamine differs from 3-fluoroamphetamine and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood–brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by this substitution.[2][3]

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CAS Number
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2-Fluoroamphetamine
Legal status
Legal status
Identifiers
  • 1-(2-Fluorophenyl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H12FN
Molar mass153.200 g·mol−1
3D model (JSmol)
  • CC(CC1=CC=CC=C1F)N
  • InChI=1S/C9H12FN/c1-7(11)6-8-4-2-3-5-9(8)10/h2-5,7H,6,11H2,1H3 checkY
  • Key:GDSXNLDTQFFIEU-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)
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1 gram of 2-FA

Pharmacology

Anorexiant dose (amount inhibiting food intake by 50% for 2 hours, given 1 hour earlier) = 15 mg/kg (rat; p.o.).[4][medical citation needed]

Analgesic dose (50% inhibition of response to tail-clamp) = 20 mg/kg (mouse; i.p.).[4][medical citation needed]

Effect on blood pressure: 0.5 mg/kg (rat; i.v.) produces an increase in BP of 29 mm.[4][medical citation needed]

Toxicology

LD50 (mouse; i.p.) = 100 mg/kg.[4][medical citation needed]

Legal status

United States

The Federal Analogue Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended (ref 1) for human consumption. 2-FA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act, if, as stated above, it is intended for human consumption.

China

As of October 2015 2-FA is a controlled substance in China.[5]

Finland

Scheduled in the "government decree on substances, preparations and plants considered to be narcotic drugs" and is hence illegal.[6]

See also

References

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