2-MDP
Chemical compound
From Wikipedia, the free encyclopedia
2-MDP (U-23807A) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. The levo or (−)-isomer is the active form of the drug.[1][2] It also has stimulant effects, having only around one third the potency of amphetamine by weight, but with a long duration of action, lasting more than 24 hours from a single oral dose.[3]
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| Formula | C16H19NO |
| Molar mass | 241.334 g·mol−1 |
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Effects
The therapeutic action is said to exhibit appetite suppressant- and antidepressant-like activity.[4]
Synthesis
In a variation of the nitrile-aldol reaction, combination of benzophenone (1) and propionitrile (2), in the presence of sodamide base and ethyl ether solvent, leads to 3-hydroxy-2-methyl-3,3-diphenylpropanenitrile (3).[5] The reduction of the intermediate nitrile group with lithium aluminium hydride completes the synthesis of 2-MDP (4).