2-Phenylmorpholine
Pharmaceutical compound
From Wikipedia, the free encyclopedia
2-Phenylmorpholine (code name PAL-632) is the parent compound of the substituted phenylmorpholine class of compounds.[1] Examples of 2-phenylmorpholine derivatives (i.e., substituted phenylmorpholines) include phenmetrazine (3-methyl-2-phenylmorpholine), phendimetrazine ((2S,3S)-3,4-dimethyl-2-phenylmorpholine), and pseudophenmetrazine ((2RS,3SR)-3-methyl-2-phenylmorpholine), which are monoamine releasing agents (MRAs) and psychostimulants.[1][2][3][4] 2-Phenylmorpholine itself is a potent norepinephrine–dopamine releasing agent (NDRA) and hence may act as a stimulant similarly.[5]
| Compound | NE | DA | 5-HT | Ref |
|---|---|---|---|---|
| Phenethylamine | 10.9 | 39.5 | >10,000 | [6][7][8] |
| Dextroamphetamine | 6.6–10.2 | 5.8–24.8 | 698–1,765 | [9][10][8][11] |
| Dextromethamphetamine | 12.3–14.3 | 8.5–40.4 | 736–1,292 | [9][12][8][11] |
| 2-Phenylmorpholine | 79 | 86 | 20,260 | [5] |
| Phenmetrazine | 29–50.4 | 70–131 | 7,765–>10,000 | [4][8][13][5] |
| Phendimetrazine | >10,000 | >10,000 | >100,000 | [4][8][11] |
| Pseudophenmetrazine | 514 | >10,000 (RI) | >10,000 | [4] |
| Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Refs: [2][3] | ||||
Other namesPAL-632; PAL632
| |
| Clinical data | |
|---|---|
| Other names | PAL-632; PAL632 |
| Drug class | Norepinephrine–dopamine releasing agent; Psychostimulant |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C10H13NO |
| Molar mass | 163.220 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
