3C-DFM

3C-DFM, also known as 4-(2,2-difluoromethoxy)-3,5-dimethoxyamphetamine or as or as α-methyldifluoromescaline (3C-difluoromescaline), is a serotonin receptor modulator of the phenethylamine and 3C families.^[1][2][3] It is the amphetamine (α-methyl) derivative of the psychedelic drug difluoromescaline (DFM).^[1][2][3] The properties and effects of 3C-DFM in humans are unknown.^[1][2] The drug shows affinity for the serotonin 5-HT₂ receptors and is known to act as an agonist of the serotonin 5-HT_2A and 5-HT_2B receptors.^[3][2] 3C-DFM was first described in the scientific literature by Daniel Trachsel by 2012.^[2][1][3] It is a controlled substance in Ukraine.^[4] The drug is also a controlled substance in Canada under phenethylamine blanket-ban language.^[5]

Other names3C-Difluoromescaline; α-Methyldifluoromescaline; 4-(2,2-Difluoromethoxy)-3,5-dimethoxyamphetamine; 3,5-Dimethoxy-4-(2,2-difluoromethoxy)amphetamine; 4-Difluoromethoxy-3,5-dimethoxyamphetamine; 3,5-Dimethoxy-4-difluoromethoxyamphetamine

Drug classSerotonin receptor modulator; Serotonin 5-HT_2A receptor agonist

ATC code

• None

PubChem CID

• 54929188

Quick facts Clinical data, Other names ...

3C-DFM

Clinical data
Other names	3C-Difluoromescaline; α-Methyldifluoromescaline; 4-(2,2-Difluoromethoxy)-3,5-dimethoxyamphetamine; 3,5-Dimethoxy-4-(2,2-difluoromethoxy)amphetamine; 4-Difluoromethoxy-3,5-dimethoxyamphetamine; 3,5-Dimethoxy-4-difluoromethoxyamphetamine
Drug class	Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist
ATC code	None
Identifiers
IUPAC name 1-[4-(difluoromethoxy)-3,5-dimethoxyphenyl]propan-2-amine
PubChem CID	54929188
ChemSpider	33248925
Chemical and physical data
Formula	C12H17F2NO3
Molar mass	261.269 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(CC1=CC(=C(C(=C1)OC)OC(F)F)OC)N
InChI InChI=1S/C12H17F2NO3/c1-7(15)4-8-5-9(16-2)11(18-12(13)14)10(6-8)17-3/h5-7,12H,4,15H2,1-3H3 Key:BQVYKMZBEBFRIG-UHFFFAOYSA-N

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