4-HO-DALT
Pharmaceutical compound
From Wikipedia, the free encyclopedia
4-HO-DALT, also known as 4-hydroxy-N,N-diallyltryptamine or as daltocin, is a serotonin receptor agonist and serotonergic psychedelic of the tryptamine and 4-hydroxytryptamine families.[1][2][3] It has been encountered as a novel designer drug.[4]
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| Other names | 4-Hydroxy-N,N-diallyltryptamine; 4-Hydroxy-DALT; 4-OH-DALT; Daltocin; Dalocin |
| Drug class | Serotonin receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Formula | C16H20N2O |
| Molar mass | 256.349 g·mol−1 |
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Use and effects
4-HO-DALT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[5] However, in a subsequently released entry, it was briefly mentioned.[5] He does not appear to have synthesized or tested it and its properties were not described, but Shulgin hypothesized that the drug, in its prodrug form 4-AcO-DALT, would have a very rapid onset of action.[5] Subsequently, 4-HO-DALT has emerged as a novel designer drug.[4] It is said to produce hallucinogenic effects similar to those of 4-HO-DiPT and 4-HO-DPT.[4]
Interactions
Pharmacology
Pharmacodynamics
4-HO-DALT binds to many of the serotonin receptors, including the serotonin 5-HT2A receptor, as well as other targets.[1][2] The drug acts as a potent full agonist of the serotonin 5-HT2A and 5-HT2B receptors, whereas it showed 60-fold lower potency as an agonist of the serotonin 5-HT2C receptor compared to the serotonin 5-HT2A receptor.[2] It produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.[1]
Chemistry
Analogues
Analogues of 4-HO-DALT include diallyltryptamine (DALT), 4-AcO-DALT, 5-MeO-DALT, 4-HO-MALT, psilocin (4-HO-DMT), 4-HO-DET (ethocin), 4-HO-DPT, and 4-HO-DiPT, among others.
History
4-HO-DALT was first described by Alexander Shulgin in a follow-up entry of TiHKAL (Tryptamines I Have Known and Loved) in 2004.[5] Subsequently, it was further described in 2017 and thereafter.[3][1][2] The drug was encountered online as a novel designer drug by 2014.[4] In 2023, it was found to be sold as an analytical standard.[4]
Society and culture
Legal status
Canada
4-HO-DALT is not a controlled substance in Canada as of 2025.[6]