4-HO-NET
Pharmaceutical compound
From Wikipedia, the free encyclopedia
4-HO-NET, also known as 4-hydroxy-N-ethyltryptamine, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to norpsilocin (4-HO-NMT).[1] It was not included by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown.[2] The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor.[1] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 13-fold lower potency than psilocin (4-HO-DMT).[1] Unlike 4-HO-NET, norpsilocin is notably inactive in this test.[1] In addition to its psychedelic-like effects, 4-HO-NET produces hypolocomotion and hypothermia in rodents.[1] 4-HO-NET was first described in the scientific literature by Alexander Sherwood and colleagues by 2024.[1]
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| Other names | 4-Hydroxy-N-ethyltryptamine |
| Drug class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Formula | C12H16N2O |
| Molar mass | 204.273 g·mol−1 |
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See also
- Substituted tryptamine
- 4-HO-DET (ethocin)
