4-HO-PiPT

Chemical compound From Wikipedia, the free encyclopedia

4-HO-PiPT, also known as 4-hydroxy-N-propyl-N-isopropyltryptamine or as piprocin, is a substituted tryptamine derivative which is claimed to have psychedelic effects.[1] It has been encountered as a novel designer drug.[2]

Other names4-Hydroxy-N-propyl-N-isopropyltryptamine; Piprocin
Routes of
administrationOral
Drug classNon-selective serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
CAS Number
Quick facts Clinical data, Other names ...
4-HO-PiPT
Clinical data
Other names4-Hydroxy-N-propyl-N-isopropyltryptamine; Piprocin
Routes of
administration		Oral
Drug classNon-selective serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
Identifiers
  • 3-{2-[(propan-2-yl)(propyl)amino]ethyl}-1H-indol-4-ol
CAS Number
PubChem CID
Chemical and physical data
FormulaC16H24N2O
Molar mass260.381 g·mol−1
3D model (JSmol)
  • CC(C)N(CCC)CCc1c[NH]c2cccc(O)c21
  • InChI=1S/C16H24N2O/c1-4-9-18(12(2)3)10-8-13-11-17-14-6-5-7-15(19)16(13)14/h5-7,11-12,17,19H,4,8-10H2,1-3H3
  • Key:CUTUPKOZXNFVHK-UHFFFAOYSA-N
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Use and effects

4-HO-EPT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[3]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

4-HO-PiPT acts as a serotonin 5-HT2A receptor agonist, with an EC50Tooltip half-maximal effective concentration of 13.8 nM and an efficacy of 104.8%.[4]

Chemistry

Analogues

Analogues of 4-HO-PiPT include propylisopropyltryptamine (PiPT), 5-MeO-PiPT, 4-HO-MiPT, 4-HO-EiPT, 4-HO-EiBT, 4-HO-DiPT, 4-HO-DsBT, 4-HO-McPT, and 4-HO-McPeT, among others.

History

4-HO-PiPT has been sold as a designer drug, first being identified in 2021 in British Columbia, Canada.[2]

Society and culture

Canada

4-HO-PiPT is not a controlled substance in Canada as of 2025.[5]

See also

References

External links

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