4-Methylephedrine
Pharmaceutical compound
From Wikipedia, the free encyclopedia
4-Methylephedrine (4-ME) — an organic compound, a substituted amphetamine and a derivative of methamphetamine, it is a metabolite of mephedrone. It belongs to the group of central nervous system stimulants and monoamine-releasing agents, although it did not increase extracellular dopamine levels.[1][2][3][4][5][6][4][7][1]
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| Pronunciation | /ˌfɔːr mɛθəlɪˈfɛdrɪn/ |
| Other names | Dihydromephedrone |
| Drug class | stimulant; monoamine releasing agent |
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| Formula | C11H17NO |
| Molar mass | 179.263 g·mol−1 |
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| Density | 0.987 to 1.00 g/cm3 |
| Melting point | 56.1 to 89.0 °C (133.0 to 192.2 °F) |
| Boiling point | 269 to 281 °C (516 to 538 °F) |
| Solubility in water | 1.61e-2 to 0.110 (water) mg/mL (20 °C) |
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Pharmacology
Pharmacodynamics
In vitro, 4-methylephedrine acts as a weak monoamine releaser, with potency significantly lower than that of the parent drug mephedrone. This agent is a weak releaser of norepinephrine, dopamine, and serotonin (SNDRA), with IC50 values of 64.98 nM, 23.97 nM, and 23.53 nM for the serotonin, norepinephrine, and dopamine transporters, respectively.[7][8]
| Compound | NE | DA | SERT | Ref |
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| Dihydromephedrone | 23.97 (8.65–66.46) | 23.53 (19.8–27.97) | 64.98 (50.66–83.37) | [8][1] |
| Mephedrone | 0.77 (0.53–1.08) | 2.77 (1.92–3.97) | 7.83 (6.32–9.75) | [8] |
| Normephedrone | 6.35 (4.66–8.64) | 5.46 (3.58–8.31) | 10.61 (9.06–12.43) | [8][1] |
| 4-hydroxymephedrone | 2.92 (2.35–3.6) | 4.85 (3.28–7.17) | 73.53 (62.5–86.51) | [8][1] |
| Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. | ||||