5-MeO-NET
Chemical compound
From Wikipedia, the free encyclopedia
5-MeO-NET, also known as 5-methoxy-N-ethyltryptamine, is a serotonin receptor agonist and serotonin releasing agent of the tryptamine family.[1][2][3]
- None
 | |
 | |
| Clinical data | |
|---|---|
| Other names | 5-Methoxy-N-ethyltryptamine |
| Drug class | Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonin releasing agent[1][2] |
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C13H18N2O |
| Molar mass | 218.300 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Use and effects
5-MeO-NET was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[4]
Pharmacology
Pharmacodynamics
5-MeO-NET is a potent full agonist or near-full agonist of the serotonin 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT2C receptors.[1][2] The drug is a relatively weak serotonin releasing agent.[2]
It does not produce the head-twitch response (HTR), a behavioral proxy of psychedelic effects, in rodents, suggesting that it would not be hallucinogenic in humans.[1] However, 5-MeO-NET does produce the HTR if it is coadministered with a serotonin 5-HT1A receptor antagonist like WAY-100635, suggesting that its serotonin 5-HT1A receptor agonism masks or blocks its own serotonin 5-HT2A receptor-mediated HTR induction.[1]
Chemistry
5-MeO-NET, chemically known as 5-methoxy-N-ethyltryptamine, is a synthetic substituted tryptamine and a N-Ethyltryptamine derivative.
Analogues
Analogues of 5-MeO-NET include N-Ethyltryptamine (NET), 4-HO-NET, 4-AcO-NET, αET, 4-HO-αET, 5-MeO-αET, 5-chloro-αMT (PAL-542), 5-fluoro-αET (PAL-545), 5-MeO-MET, 5-MeO-DMT, 5-MeO-DET, 5-MeO-MPT, 5-MeO-EPT, 5-MeO-MALT, and 5-MeO-MiPT, among others.[1]
History
5-MeO-NET was first described in the scientific literature by at least 1994.[3] Research on 5-MeO-NET since the early 2000s has primarily focused on its interactions with serotonin receptors and other targets, as well as behavioral effects in rodent models.[1][2]