RU-28253

RU-28253, also known as 5-MeO-THPI, is a non-selective serotonin receptor agonist of the tryptamine, 5-methoxytryptamine, and tetrahydropyridinylindole families.^[1][2][3][4] It is a tetrahydropyridylindole and a conformationally constrained analogue of 5-MeO-DMT.^[2][3]

Other namesRU28253; 5-MeO-THPI

Drug classNon-selective serotonin receptor agonist

ATC code

• None

PubChem CID

• 10220205

Quick facts Clinical data, Other names ...

RU-28253

Clinical data
Other names	RU28253; 5-MeO-THPI
Drug class	Non-selective serotonin receptor agonist
ATC code	None
Identifiers
IUPAC name 5-methoxy-3-(1,2,3,6-tetrahydropyridin-5-yl)-1H-indole
PubChem CID	10220205
ChemSpider	8395697
ChEMBL	ChEMBL101487
Chemical and physical data
Formula	C14H16N2O
Molar mass	228.295 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC2=C(C=C1)NC=C2C3=CCCNC3
InChI InChI=1S/C14H16N2O/c1-17-11-4-5-14-12(7-11)13(9-16-14)10-3-2-6-15-8-10/h3-5,7,9,15-16H,2,6,8H2,1H3 Key:WBJMGSVSSCEGFV-UHFFFAOYSA-N

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The drug shows high affinity for the serotonin 5-HT_1A receptor (K_i = 5.7 nM) and lower affinity for the serotonin 5-HT_2A receptor (K_i = 230 nM).^[2] Its affinities for these receptors were higher than those of dimethyltryptamine (DMT).^[2] RU-28253 is described as a potent agonist of the serotonin 5-HT₁ and 5-HT₂ receptors,^[5] including of the serotonin 5-HT_1B receptor,^[6] and is also an agonist of the serotonin 5-HT₄ receptor.^[3][7]

RU-28253 was first described in the scientific literature by 1983.^[8][9][2]