6-MeO-RU-28306

6-MeO-RU-28306, or 6-methoxy-RU-28306, also known as 4,α-methylene-5-methoxy-N,N-dimethyltryptamine (4,α-methylene-5-MeO-DMT), is a serotonin receptor modulator and a cyclized tryptamine and partial ergoline.^[1] It is the 6-methoxy derivative of RU-28306 (4,α-methylene-DMT) and a cyclized derivative of 5-MeO-DMT.^[1] The drug showed affinity for the serotonin-labeled serotonin 5-HT₁ receptors and spiperone-labeled serotonin 5-HT₂ receptors in rat frontal cortex membranes in vitro (IC₅₀Tooltip half-maximal inhibitory concentration = 96 nM and 1,756 nM, respectively).^[1] 6-MeO-RU-28306 robustly reduced hypothalamic 5-hydroxyindoleacetic acid (5-HIAA) levels and increased circulating corticosterone levels in rodents in vivo, which are both measures of serotonin receptor agonist activity.^[1] The chemical synthesis of 6-MeO-RU-28306 has been described.^[1] 6-MeO-RU-28306 was first described in the scientific literature by 1988.^[1]

Other names6-Methoxy-RU-28306; 6-MeO-RU28306; 6-Methoxy-RU28306; 4,α-Methylene-5-methoxy-N,N-dimethyltryptamine; 4,α-Methylene-5-MeO-DMT

Drug classSerotonin receptor modulator

ATC code

• None

PubChem CID

• 13356524

Quick facts Clinical data, Other names ...

6-MeO-RU-28306

Clinical data
Other names	6-Methoxy-RU-28306; 6-MeO-RU28306; 6-Methoxy-RU28306; 4,α-Methylene-5-methoxy-N,N-dimethyltryptamine; 4,α-Methylene-5-MeO-DMT
Drug class	Serotonin receptor modulator
ATC code	None
Identifiers
IUPAC name 6-methoxy-N,N-dimethyl-1,3,4,5-tetrahydrobenzo[cd]indol-4-amine
PubChem CID	13356524
ChemSpider	14542283
ChEMBL	ChEMBL49309
Chemical and physical data
Formula	C14H18N2O
Molar mass	230.311 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)C1CC2=CNC3=C2C(=C(C=C3)OC)C1
InChI InChI=1S/C14H18N2O/c1-16(2)10-6-9-8-15-12-4-5-13(17-3)11(7-10)14(9)12/h4-5,8,10,15H,6-7H2,1-3H3 Key:ZHSVGDFOQZTIEK-UHFFFAOYSA-N

Close