AADAC

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.^[5][6]

AliasesAADAC, CES5A1, DAC, arylacetamide deacetylase

External IDsOMIM: 600338; MGI: 1915008; HomoloGene: 37436; GeneCards: AADAC; OMA:AADAC - orthologs

EC number3.1.1.3

Chr.Chromosome 3 (human)^[1]

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AADAC
Identifiers
Aliases	AADAC, CES5A1, DAC, arylacetamide deacetylase
External IDs	OMIM: 600338; MGI: 1915008; HomoloGene: 37436; GeneCards: AADAC; OMA:AADAC - orthologs
EC number	3.1.1.3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 151,814,073 bp[1] End 151,828,488 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 D Start 59,933,138 bp[2] End 59,947,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver duodenum mucosa of ileum body of pancreas gallbladder Top expressed in left lobe of liver right kidney proximal tubule duodenum human kidney precursor cell migratory enteric neural crest cell fetal liver hematopoietic progenitor cell gallbladder jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function serine hydrolase activity carboxylic ester hydrolase activity catalytic activity hydrolase activity lipase activity deacetylase activity triglyceride lipase activity Cellular component organelle membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process xenobiotic metabolic process metabolism positive regulation of triglyceride catabolic process catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 13 67758 Ensembl ENSG00000114771 ENSMUSG00000027761 UniProt P22760 Q99PG0 RefSeq (mRNA) NM_001086 NM_023383 RefSeq (protein) NP_001077 NP_075872 Location (UCSC) Chr 3: 151.81 – 151.83 Mb Chr 3: 59.93 – 59.95 Mb PubMed search [3] [4]
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Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.^[6]