AATK
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[5][6][7]
AliasesAATK, AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP, apoptosis-associated tyrosine kinase, aatyk1, mKIAA0641, apoptosis associated tyrosine kinase
External IDsOMIM: 605276; MGI: 1197518; HomoloGene: 74861; GeneCards: AATK; OMA:AATK - orthologs
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| Aliases | AATK, AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP, apoptosis-associated tyrosine kinase, aatyk1, mKIAA0641, apoptosis associated tyrosine kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605276; MGI: 1197518; HomoloGene: 74861; GeneCards: AATK; OMA:AATK - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Structure and expression
Function
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[7][8] Its suppressive role on melanoma development has been reported recently.[9]
AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.[10]
