AB0124

AB0124 is a serotonin 5-HT_2A receptor positive allosteric modulator.^[1][2][3] It is highly selective for potentiation of the serotonin 5-HT_2A receptor, with no potentiation of the serotonin 5-HT_2B and 5-HT_2C receptors.^[1][2] In addition, it showed no orthosteric agonistic activity at any of the serotonin 5-HT₂ receptors.^[1] AB0124 has been studied in combination with the serotonin 5-HT₂ receptor agonist (R)-DOI in animal models of cocaine use disorder.^[2][1] The chemical synthesis of AB0124 has been described.^[3] The drug was patented in 2022^[3] and was first described in the scientific literature by 2024.^[2][1]

Other namesAB-0124; ABO124; ABO-124

Drug classSerotonin 5-HT_2A receptor positive allosteric modulator

PubChem CID

• 167475110

FormulaC₁₈H₂₉N₃O

Quick facts Clinical data, Other names ...

AB0124

Clinical data
Other names	AB-0124; ABO124; ABO-124
Drug class	Serotonin 5-HT2A receptor positive allosteric modulator
Identifiers
IUPAC name N-[2-(dimethylamino)ethyl]-4-(2-phenylethyl)piperidine-2-carboxamide
PubChem CID	167475110
Chemical and physical data
Formula	C18H29N3O
Molar mass	303.450 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCNC(=O)C1CC(CCN1)CCC2=CC=CC=C2
InChI InChI=1S/C18H29N3O/c1-21(2)13-12-20-18(22)17-14-16(10-11-19-17)9-8-15-6-4-3-5-7-15/h3-7,16-17,19H,8-14H2,1-2H3,(H,20,22) Key:YAFSEZSVGMQXTE-UHFFFAOYSA-N

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