ASIC4
Protein found in humans
From Wikipedia, the free encyclopedia
Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is encoded by the ASIC4 gene. The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals.[5] The cDNA of this gene was first cloned in 2000.[6][7] The ASIC genes have splicing variants that encode different proteins that are called isoforms.
| ASIC4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ASIC4, ACCN4, BNAC4, acid sensing ion channel subunit family member 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606715; MGI: 2652846; HomoloGene: 11166; GeneCards: ASIC4; OMA:ASIC4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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These genes are mainly expressed in the central and peripheral nervous system.
ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.[8]
Structure and function
This gene encodes a member of the ASIC/ENaC superfamily of proteins.[9] The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).
The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer.[5]