ACP2

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.^[5][6]

AliasesACP2, acid phosphatase 2, lysosomal, LAP

External IDsOMIM: 171650; MGI: 87882; HomoloGene: 1217; GeneCards: ACP2; OMA:ACP2 - orthologs

Chr.Chromosome 11 (human)^[1]

End47,248,906 bp^[1]

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ACP2
Identifiers
Aliases	ACP2, acid phosphatase 2, lysosomal, LAP
External IDs	OMIM: 171650; MGI: 87882; HomoloGene: 1217; GeneCards: ACP2; OMA:ACP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2|11p12-p11 Start 47,239,302 bp[1] End 47,248,906 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E1|2 50.54 cM Start 91,033,230 bp[2] End 91,044,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver body of pancreas right adrenal gland left adrenal gland right adrenal cortex stromal cell of endometrium jejunal mucosa left adrenal cortex mucosa of transverse colon salivary gland Top expressed in spermatocyte medial dorsal nucleus stroma of bone marrow spermatid dentate gyrus of hippocampal formation granule cell choroid plexus of fourth ventricle medial geniculate nucleus ascending aorta aortic valve genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity acid phosphatase activity Cellular component integral component of membrane lysosomal membrane lysosome lysosomal lumen extracellular exosome membrane Biological process skeletal system development lysosome organization dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53 11432 Ensembl ENSG00000134575 ENSMUSG00000002103 UniProt P11117 P24638 RefSeq (mRNA) NM_001131064 NM_001302489 NM_001302490 NM_001302491 NM_001302492 NM_001610 NM_001357016 NM_007387 NM_001357067 RefSeq (protein) NP_001289418 NP_001289419 NP_001289420 NP_001289421 NP_001601 NP_001343945 NP_031413 NP_001343996 Location (UCSC) Chr 11: 47.24 – 47.25 Mb Chr 2: 91.03 – 91.04 Mb PubMed search [3] [4]
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Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.^[6]