ACSBG1

Acyl-CoA Synthetase, Bubblegum Family, member 1 (ACSBG1) is an enzyme that in humans is encoded by the ACSBG1 gene.^[5][6][7]

AliasesACSBG1, BG, BG1, BGM, GR-LACS, LPD, acyl-CoA synthetase bubblegum family member 1

External IDsOMIM: 614362; MGI: 2385656; HomoloGene: 9044; GeneCards: ACSBG1; OMA:ACSBG1 - orthologs

Chr.Chromosome 15 (human)^[1]

End78,245,688 bp^[1]

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ACSBG1
Identifiers
Aliases	ACSBG1, BG, BG1, BGM, GR-LACS, LPD, acyl-CoA synthetase bubblegum family member 1
External IDs	OMIM: 614362; MGI: 2385656; HomoloGene: 9044; GeneCards: ACSBG1; OMA:ACSBG1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 78,167,468 bp[1] End 78,245,688 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 54,512,161 bp[2] End 54,569,154 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh inferior olivary nucleus C1 segment dorsal motor nucleus of vagus nerve endothelial cell internal globus pallidus putamen caudate nucleus skin of arm substantia nigra Top expressed in lip cerebellar cortex deep cerebellar nuclei adrenal gland skin of external ear visual cortex esophagus lobe of cerebellum superior frontal gyrus primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity catalytic activity ATP binding decanoate-CoA ligase activity long-chain fatty acid-CoA ligase activity very long-chain fatty acid-CoA ligase activity Cellular component cytosol intracellular membrane-bounded organelle endoplasmic reticulum cytoplasmic vesicle cytoplasm Biological process lipid metabolism very long-chain fatty acid metabolic process response to glucocorticoid fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process myelination metabolism long-chain fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23205 94180 Ensembl ENSG00000103740 ENSMUSG00000032281 UniProt Q96GR2 Q99PU5 RefSeq (mRNA) NM_001199377 NM_015162 NM_053178 RefSeq (protein) NP_001186306 NP_055977 NP_444408 Location (UCSC) Chr 15: 78.17 – 78.25 Mb Chr 9: 54.51 – 54.57 Mb PubMed search [3] [4]
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The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis.^[7] The conversion of long chain fatty acids into long chain acyl-CoAs in mice is catalysed by ACSBG1.^[8]