ACTG2

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.^[5][6][7]

AliasesACTG2, ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, actin, gamma 2, smooth muscle, enteric, actin gamma 2, smooth muscle, VSCM1, MMIHS5

External IDsOMIM: 102545; MGI: 104589; HomoloGene: 123845; GeneCards: ACTG2; OMA:ACTG2 - orthologs

Chr.Chromosome 2 (human)^[1]

End73,919,865 bp^[1]

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ACTG2
Identifiers
Aliases	ACTG2, ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, actin, gamma 2, smooth muscle, enteric, actin gamma 2, smooth muscle, VSCM1, MMIHS5
External IDs	OMIM: 102545; MGI: 104589; HomoloGene: 123845; GeneCards: ACTG2; OMA:ACTG2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 73,892,314 bp[1] End 73,919,865 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 35.94 cM Start 83,489,887 bp[2] End 83,513,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula tail of epididymis saphenous vein muscle layer of sigmoid colon gastric mucosa popliteal artery tibial arteries prostate myometrium urethra Top expressed in umbilical cord migratory enteric neural crest cell cervix left colon ileum seminal vesicula pyloric antrum seminiferous tubule gallbladder esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATP binding Cellular component cytoplasm filopodium cell body myosin filament cytosol blood microparticle extracellular exosome cytoskeleton cell periphery lamellipodium extracellular space Biological process mesenchyme migration positive regulation of gene expression muscle contraction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 72 11468 Ensembl ENSG00000163017 ENSMUSG00000059430 UniProt P63267 P63268 RefSeq (mRNA) NM_001615 NM_001199893 NM_009610 RefSeq (protein) NP_001186822 NP_001606 NP_033740 Location (UCSC) Chr 2: 73.89 – 73.92 Mb Chr 6: 83.49 – 83.51 Mb PubMed search [3] [4]
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Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.^[7]