ADAM18

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.^[5][6]

AliasesADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18

External IDsMGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs

Chr.Chromosome 8 (human)^[1]

End39,730,065 bp^[1]

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ADAM18
Identifiers
Aliases	ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDs	MGI: 105986; HomoloGene: 74941; GeneCards: ADAM18; OMA:ADAM18 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 39,584,489 bp[1] End 39,730,065 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 25,092,262 bp[2] End 25,164,771 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis testicle gonad monocyte right coronary artery apex of heart left ventricle urinary bladder Top expressed in spermatocyte spermatid seminiferous tubule visual cortex primary visual cortex superior frontal gyrus islet of Langerhans somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metalloendopeptidase activity metallopeptidase activity Cellular component integral component of membrane membrane Biological process multicellular organism development cell differentiation spermatogenesis proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8749 13524 Ensembl ENSG00000168619 ENSG00000278548 ENSMUSG00000031552 UniProt Q9Y3Q7 Q9R157 RefSeq (mRNA) NM_001190956 NM_014237 NM_001320313 NM_010084 RefSeq (protein) NP_001177885 NP_001307242 NP_055052 NP_034214 Location (UCSC) Chr 8: 39.58 – 39.73 Mb Chr 8: 25.09 – 25.16 Mb PubMed search [3] [4]
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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.^[6]