ADL-5859

Selective delta opioid receptor agonist From Wikipedia, the free encyclopedia

ADL-5859, also known as compound 20, is an opioid drug that is selective for the δ-opioid receptor, it is being investigated as an alternative to traditional opioids in pain management.

Quick facts Names, Identifiers ...
ADL-5859
Names
IUPAC name
N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
UNII
  • InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)18-10-8-17(9-11-18)19-16-24(12-14-25-15-13-24)29-21-7-5-6-20(27)22(19)21/h5-11,16,25,27H,3-4,12-15H2,1-2H3
    Key: OPIKUXLJQFYMSC-UHFFFAOYSA-N
  • CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC(=C42)O
Properties
C24H28N2O3
Molar mass 392.499 g·mol−1
Related compounds
Related compounds
 ADL-5747
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mechanism of action

Like all opioid drugs, ADL-5859 activates opioid receptors, but where as traditional opioids (such as oxycodone) activate the three main receptors (mu, delta, and kappa), ADL-5859 appears to be selective and only activates the delta receptor.[1] with a Ki of 20 nM

Therapeutic potential

Like other opioids, it has potential in pain management; however, by being selective for the delta receptor, multiple undesirable side effects of traditional opioids are not present, such as respiratory depression, sedation, and euphoria.

ADL-5859 was also found to be orally active, which makes it easier to administer.[2]

Multiple tests have shown its efficacy as an analgesic.[3][1] It also did not seem to be a convulsant, unlike some other delta agonist opioids.[4]

References

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