ADX-47273

ADX-47273
Identifiers
	IUPAC name (S)-(4-fluorophenyl)-(3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]piperidin-1-yl)methanone;
CAS Number	851881-60-2 ; 851881-59-9 (R isomer),; 837413-22-6 (racemate);
PubChem CID	11383075;
IUPHAR/BPS	1420;
ChemSpider	9557988 ;
UNII	4C4P7L0W63;
ChEMBL	ChEMBL381055 ;
CompTox Dashboard (EPA)	DTXSID80234386 ;
Chemical and physical data
Formula	C20H17F2N3O2
Molar mass	369.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC1=CC=C(C(N2CCC[C@@H](C2)C3=NC(C4=CC=C(F)C=C4)=NO3)=O)C=C1;
	InChI InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1 ; Key:VXQCCZHCFBHTTD-HNNXBMFYSA-N ;
	(verify)

ADX-47273 is a research pharmaceutical developed by Addex Therapeutics which acts as a positive allosteric modulator (PAM) selective for the metabotropic glutamate receptor subtype mGluR₅.^[1]^[2] It has nootropic and antipsychotic effects in animal studies,^[3] and has been used as a lead compound to develop improved derivatives.^[4]

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Identifiers

IUPAC name (S)-(4-fluorophenyl)-(3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]piperidin-1-yl)methanone
CAS Number	851881-60-2^Y 851881-59-9 (R isomer), 837413-22-6 (racemate)
PubChem CID	11383075
IUPHAR/BPS	1420
ChemSpider	9557988^Y
UNII	4C4P7L0W63
ChEMBL	ChEMBL381055^Y
CompTox Dashboard (EPA)	DTXSID80234386
Chemical and physical data
Formula	C₂₀H₁₇F₂N₃O₂
Molar mass	369.372 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES FC1=CC=C(C(N2CCC[C@@H](C2)C3=NC(C4=CC=C(F)C=C4)=NO3)=O)C=C1
InChI InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1^Y Key:VXQCCZHCFBHTTD-HNNXBMFYSA-N^Y
(verify)