ADX-71441
Chemical compound
From Wikipedia, the free encyclopedia
ADX-71441 is a GABAB receptor positive allosteric modulator currently being investigated as a potential treatment for anxiety, epilepsy, pain and other conditions.
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| Names | |
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| IUPAC name
N-[5-[4-[(4-chloro-3-fluorophenyl)methyl]-6-methoxy-3,5-dioxo-1,2,4-triazin-2-yl]-2-fluorophenyl]acetamide | |
| Identifiers | |
3D model (JSmol) |
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PubChem CID |
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| Properties | |
| C19H15ClF2N4O4 | |
| Molar mass | 436.80 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Therapeutic potential
Addiction
ADX-71441 has been shown to reduce alcohol consumption.[1] This result was observed in both alcohol dependent and non-dependent animals.[2][3]
There were also trials about nicotine addiction, which showed positive results: ADX-71441 was able to decrease some withdrawal symptoms of nicotine withdrawal.[4]
Anxiety
This compound has also been shown to reduce anxiety in people with PTSD.[5]
Pain
Experiments have shown that this compound was able to decrease hypersensitivity to pain in mice, Guinea pigs and rats.[5]