AFTPH

Available protein structures:
PDB	IPR029205 PF15045 (ECOD; PDBsum)
AlphaFold	IPR029205; PF15045;

Clathrin-binding box of Aftiphilin
Clathrin-binding box of Aftiphilin
Identifiers
Symbol	Clathrin_bdg
Pfam	PF15045
InterPro	IPR029205
PDB
Available protein structures:
PDB	IPR029205 PF15045 (ECOD; PDBsum)
AlphaFold	IPR029205; PF15045;

AFTPH
Identifiers
Aliases	AFTPH, Nbla10388, aftiphilin
External IDs	MGI: 1923012; HomoloGene: 9764; GeneCards: AFTPH; OMA:AFTPH - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	64,593,005 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,691,589 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; male germ cell; ; sperm; ; buccal mucosa cell; ; cardia; ; epithelium of nasopharynx; ; cerebellar vermis; ; mucosa of ileum; ; beta cell; ; pylorus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; spermatocyte; ; submandibular gland; ; lacrimal gland; ; dorsomedial hypothalamic nucleus; ; neural layer of retina; ; habenula; ; vestibular sensory epithelium; ; granulocyte; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding;
Cellular component	AP-1 adaptor complex; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleus; cytoplasm; trans-Golgi network membrane;
Biological process	protein transport; intracellular transport;
	Sources:Amigo / QuickGO
Orthologs
	54812
	216549
	ENSG00000119844
	ENSMUSG00000049659
	Q6ULP2
	Q80WT5
	NM_001002243; NM_017657; NM_203437
	NM_001252503; NM_001290545; NM_181411
NP_001002243; NP_060127; NP_982261; NP_001362898; NP_001362899;
	NP_001362900; NP_001362901; NP_001362902
	NP_001239432; NP_001277474; NP_852076
	Wikidata
View/Edit Human	View/Edit Mouse

Aftiphilin is a protein that in humans is encoded by the AFTPH gene.^[5]^[6]^[7] It forms a stable complex with p200 and synergin gamma.^[6]^[7] It contains a clathrin box with two known clathrin-binding sequence motifs, is involved in vesicle trafficking^[8] and is found in many eukaryotes.