AGPAT3

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene.^[5]

AliasesAGPAT3, LPAAT-GAMMA1, LPAAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3

External IDsOMIM: 614794; MGI: 1336186; HomoloGene: 10591; GeneCards: AGPAT3; OMA:AGPAT3 - orthologs

Chr.Chromosome 21 (human)^[1]

End43,987,592 bp^[1]

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AGPAT3
Identifiers
Aliases	AGPAT3, LPAAT-GAMMA1, LPAAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3
External IDs	OMIM: 614794; MGI: 1336186; HomoloGene: 10591; GeneCards: AGPAT3; OMA:AGPAT3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 43,865,223 bp[1] End 43,987,592 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 78,105,012 bp[2] End 78,188,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus Brodmann area 23 middle temporal gyrus entorhinal cortex postcentral gyrus primary visual cortex parotid gland jejunal mucosa subthalamic nucleus endothelial cell Top expressed in neural layer of retina saccule seminiferous tubule otic placode right kidney spermatid brown adipose tissue otic vesicle lip proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity lysophosphatidic acid acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity Cellular component integral component of membrane plasma membrane nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane membrane nucleus Golgi membrane Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process metabolism phospholipid biosynthetic process lipid metabolism phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56894 28169 Ensembl ENSG00000160216 ENSMUSG00000001211 UniProt Q9NRZ7 Q9D517 RefSeq (mRNA) NM_001037553 NM_020132 NM_001369878 NM_001369880 NM_001369881 NM_053014 RefSeq (protein) NP_001032642 NP_064517 NP_001356807 NP_001356809 NP_001356810 NP_443747 NP_001391799 NP_001391800 NP_001391801 NP_001391802 NP_001391803 NP_001391804 NP_001391805 NP_001391806 NP_001391807 NP_001391808 NP_001391809 NP_001391810 NP_001391811 Location (UCSC) Chr 21: 43.87 – 43.99 Mb Chr 10: 78.11 – 78.19 Mb PubMed search [3] [4]
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The protein encoded by this gene is an acyltransferase (specifically, 1-acylglycerol-3-phosphate O-acyltransferase) that converts lysophosphatidic acid (1-acyl-sn-glycerol 3-phosphate) into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.^[5]