ALDH3B2

Aldehyde dehydrogenase family 3 member B2 is an enzyme that, in humans, is encoded by the ALDH3B2 gene.^[5][6][7]

AliasesALDH3B2, ALDH8, aldehyde dehydrogenase 3 family member B2

External IDsOMIM: 601917; MGI: 1920708; GeneCards: ALDH3B2; OMA:ALDH3B2 - orthologs

Chr.Chromosome 11 (human)^[1]

End67,681,224 bp^[1]

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ALDH3B2
Identifiers
Aliases	ALDH3B2, ALDH8, aldehyde dehydrogenase 3 family member B2
External IDs	OMIM: 601917; MGI: 1920708; GeneCards: ALDH3B2; OMA:ALDH3B2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,662,155 bp[1] End 67,681,224 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,008,645 bp[2] End 4,022,103 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm vulva skin of abdomen gingival epithelium oral cavity parotid gland human penis nipple skin of hip Top expressed in granulocyte lumbar subsegment of spinal cord proximal tubule right kidney outer nuclear layer skin of back skin of external ear lip morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3-chloroallyl aldehyde dehydrogenase activity oxidoreductase activity aldehyde dehydrogenase [NAD(P)+ activity] oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Cellular component lipid droplet Biological process ethanol catabolic process metabolism alcohol metabolic process lipid metabolism sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 222 73458 Ensembl ENSG00000132746 ENSMUSG00000037263 UniProt P48448 J3QMK6 RefSeq (mRNA) NM_000695 NM_001031615 NM_001354345 NM_001393400 NM_001393401 NM_001393402 NM_028545 RefSeq (protein) NP_000686 NP_001026786 NP_001341274 NP_082821 Location (UCSC) Chr 11: 67.66 – 67.68 Mb Chr 19: 4.01 – 4.02 Mb PubMed search [3] [4]
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This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene for this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.^[7]