ALPI

Alkaline phosphatase, intestinal, also known as ALPI, is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.^[5][6] Its chemical formula is:C₂₆₇₉H₄₁₉₆O₉₆₅N₆₇₂S₁₈P₂.^[7]

AliasesALPI, IAP, alkaline phosphatase, intestinal

External IDsOMIM: 171740; MGI: 87984; HomoloGene: 134333; GeneCards: ALPI; OMA:ALPI - orthologs

Chr.Chromosome 2 (human)^[1]

End232,460,753 bp^[1]

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ALPI
Identifiers
Aliases	ALPI, IAP, alkaline phosphatase, intestinal
External IDs	OMIM: 171740; MGI: 87984; HomoloGene: 134333; GeneCards: ALPI; OMA:ALPI - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 232,456,125 bp[1] End 232,460,753 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 44.06 cM Start 87,052,695 bp[2] End 87,055,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum mucosa of ileum mucosa of transverse colon rectum human kidney muscle tissue smooth muscle tissue appendix gallbladder Top expressed in duodenum embryo jejunum temporal muscle upper arm secretory cell colon triceps brachii muscle mucous cell of stomach midbrain tectum More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding phosphatase activity zinc ion binding protein binding catalytic activity hydrolase activity magnesium ion binding metal ion binding alkaline phosphatase activity Cellular component integral component of membrane anchored component of membrane membrane extracellular region plasma membrane Biological process metabolism dephosphorylation phosphatidic acid biosynthetic process digestion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 248 11648 Ensembl ENSG00000163295 ENSMUSG00000036500 UniProt P09923 P24822 RefSeq (mRNA) NM_001631 NM_007432 RefSeq (protein) NP_001622 n/a Location (UCSC) Chr 2: 232.46 – 232.46 Mb Chr 1: 87.05 – 87.06 Mb PubMed search [3] [4]
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Intestinal alkaline phosphatase is an endogenous enzyme that maintains gut homeostasis. It detoxifyies bacterial toxins, dephosphorylates phosphorylated nucleotides, regulates lipid absorption in the intestine, and regulates the microbiome in the intestine.^[8] In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.^[9]