ALS2

ALS2
Identifiers
Aliases	ALS2, ALS2CR6, ALSJ, IAHSP, PLSJ, alsin Rho guanine nucleotide exchange factor, alsin Rho guanine nucleotide exchange factor ALS2
External IDs	OMIM: 606352; MGI: 1921268; HomoloGene: 23264; GeneCards: ALS2; OMA:ALS2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,782,112 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	59,276,390 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; tibialis anterior muscle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; deltoid muscle; ; sural nerve;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; morula; ; zygote; ; muscle of thigh; ; right kidney; ; ventricular zone; ; yolk sac; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; guanyl-nucleotide exchange factor activity; protein serine/threonine kinase activator activity; protein binding;
Cellular component	cytoplasm; vesicle; centrosome; membrane; postsynaptic density; intracellular membrane-bounded organelle; growth cone; ruffle; dendritic spine; axon; soma; dendrite; early endosome; neuron projection; lamellipodium; cytosol; protein-containing complex;
Biological process	protein localization; neuron projection morphogenesis; synaptic transmission, glutamatergic; axonogenesis; locomotory behavior; vesicle organization; regulation of GTPase activity; cell death; in utero embryonic development; behavioral fear response; response to oxidative stress; endosome organization; endosomal transport; positive regulation of GTPase activity; receptor recycling; neuromuscular junction development; Rac protein signal transduction; regulation of Rho protein signal transduction; regulation of endosome size; positive regulation of Rac protein signal transduction; positive regulation of protein kinase activity; positive regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	57679
	74018
	ENSG00000003393
	ENSMUSG00000026024
	Q96Q42
	Q920R0
	NM_001135745; NM_020919
	NM_001159948; NM_028717; NM_146109
	NP_001129217; NP_065970
	NP_001153420; NP_082993; NP_666221
	Wikidata
View/Edit Human	View/Edit Mouse

Alsin is a protein that in humans is encoded by the ALS2 gene.^[5]^[6] ALS2 orthologs^[7] have been identified in all mammals for which complete genome data are available.