ALS2CR2

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.^[5][6][7]

AliasesSTRADB, STE20-related kinase adaptor beta, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038, ALS2CR2, STE20 related adaptor beta

External IDsOMIM: 607333; MGI: 2144047; HomoloGene: 10237; GeneCards: STRADB; OMA:STRADB - orthologs

Chr.Chromosome 2 (human)^[1]

End201,480,846 bp^[1]

Quick facts STRADB, Identifiers ...

STRADB
Identifiers
Aliases	STRADB, STE20-related kinase adaptor beta, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038, ALS2CR2, STE20 related adaptor beta
External IDs	OMIM: 607333; MGI: 2144047; HomoloGene: 10237; GeneCards: STRADB; OMA:STRADB - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 201,387,858 bp[1] End 201,480,846 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.3|1 29.2 cM Start 59,012,681 bp[2] End 59,034,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex blood left adrenal gland gastrocnemius muscle left adrenal cortex muscle of thigh right lobe of liver skeletal muscle tissue duodenum rectum Top expressed in vastus lateralis muscle triceps brachii muscle knee joint sternocleidomastoid muscle medial head of gastrocnemius muscle temporal muscle blood digastric muscle tibialis anterior muscle skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase activity nucleotide binding protein binding ATP binding protein serine/threonine kinase activity Cellular component cytoplasm nucleus cytosol aggresome Biological process protein phosphorylation cell cycle negative regulation of extrinsic apoptotic signaling pathway in absence of ligand activation of protein kinase activity cell morphogenesis protein export from nucleus regulation of mitotic cell cycle stress-activated protein kinase signaling cascade regulation of apoptotic process MAPK cascade signal transduction neuron projection morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55437 227154 Ensembl ENSG00000082146 ENSMUSG00000026027 UniProt Q9C0K7 Q8K4T3 RefSeq (mRNA) NM_001206864 NM_018571 NM_172656 NM_173155 RefSeq (protein) NP_001193793 NP_061041 NP_766244 Location (UCSC) Chr 2: 201.39 – 201.48 Mb Chr 1: 59.01 – 59.03 Mb PubMed search [3] [4]
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This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.^[7]