ALS2CR8

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.^[5][6]

AliasesCARF, ALS2CR8, NYD-SP24, calcium responsive transcription factor

External IDsOMIM: 607586; MGI: 2182269; HomoloGene: 11689; GeneCards: CARF; OMA:CARF - orthologs

Chr.Chromosome 2 (human)^[1]

End202,988,263 bp^[1]

Quick facts CARF, Identifiers ...

CARF
Identifiers
Aliases	CARF, ALS2CR8, NYD-SP24, calcium responsive transcription factor
External IDs	OMIM: 607586; MGI: 2182269; HomoloGene: 11689; GeneCards: CARF; OMA:CARF - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.2 Start 202,912,214 bp[1] End 202,988,263 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 60,098,247 bp[2] End 60,153,953 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon testicle gonad ventricular zone right uterine tube sural nerve gallbladder ganglionic eminence C1 segment popliteal artery Top expressed in spermatocyte pineal gland spermatid lumbar spinal ganglion dorsal striatum seminiferous tubule medullary collecting duct superior frontal gyrus olfactory tubercle primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleolus nucleoplasm nucleus Biological process cellular response to calcium ion positive regulation of transcription from RNA polymerase II promoter in response to calcium ion regulation of transcription, DNA-templated transcription, DNA-templated cellular response to potassium ion positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79800 241066 Ensembl ENSG00000138380 ENSMUSG00000026017 UniProt Q8N187 Q8VHI4 RefSeq (mRNA) NM_001104586 NM_001282910 NM_001282911 NM_001282912 NM_024744 NM_001322427 NM_001322428 NM_001322429 NM_001322430 NM_001352676 NM_001352677 NM_001352678 NM_001352679 NM_001285463 NM_001285473 NM_139150 RefSeq (protein) NP_001098056 NP_001269839 NP_001269840 NP_001269841 NP_001309356 NP_001309357 NP_001309358 NP_079020 NP_001339605 NP_001339606 NP_001339607 NP_001339608 NP_001272392 NP_001272402 NP_631889 Location (UCSC) Chr 2: 202.91 – 202.99 Mb Chr 1: 60.1 – 60.15 Mb PubMed search [3] [4]
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Knocking out the Carf (Als2cr8) gene in mice results in learning associated deficits. Furthermore, Carf has been shown to function as a transcription factor that regulates the expression of BDNF.^[7]