AMY1A

Alpha-amylase 1 is an enzyme that in humans is encoded by the AMY1A gene.^[3] This gene is found in many organisms.

PDBHuman UniProt search: PDBe RCSB

AliasesAMY1A, AMY1, amylase, alpha 1A (salivary), amylase alpha 1A (salivary), amylase alpha 1A

External IDsOMIM: 104700; HomoloGene: 133998; GeneCards: AMY1A; OMA:AMY1A - orthologs

EC number3.2.1.1

Quick facts Available structures, PDB ...

AMY1A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP
Identifiers
Aliases	AMY1A, AMY1, amylase, alpha 1A (salivary), amylase alpha 1A (salivary), amylase alpha 1A
External IDs	OMIM: 104700; HomoloGene: 133998; GeneCards: AMY1A; OMA:AMY1A - orthologs
EC number	3.2.1.1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.1 Start 103,655,760 bp[1] End 103,664,554 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas testicle right uterine tube gonad olfactory zone of nasal mucosa tonsil right lobe of thyroid gland placenta left lobe of thyroid gland salivary gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding alpha-amylase activity hydrolase activity catalytic activity metal ion binding hydrolase activity, acting on glycosyl bonds cation binding Cellular component extracellular region extracellular exosome extracellular space Biological process digestion metabolism carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 276 n/a Ensembl ENSG00000237763 n/a UniProt P04745 n/a RefSeq (mRNA) NM_004038 NM_001008221 n/a RefSeq (protein) NP_001008220 NP_001333709 NP_001008222 NP_004029 NP_001008219 n/a Location (UCSC) Chr 1: 103.66 – 103.66 Mb n/a PubMed search [2] n/a
Wikidata
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Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein.^[3]