ANAPC1

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1

External IDsOMIM: 608473; MGI: 103097; HomoloGene: 7414; GeneCards: ANAPC1; OMA:ANAPC1 - orthologs

Chr.Chromosome 2 (human)^[1]

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ANAPC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	ANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDs	OMIM: 608473; MGI: 103097; HomoloGene: 7414; GeneCards: ANAPC1; OMA:ANAPC1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 111,611,639 bp[1] End 111,884,690 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 128,452,024 bp[2] End 128,529,311 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad epithelium of colon pancreatic ductal cell Achilles tendon testicle tibialis anterior muscle endothelial cell bone marrow cell deltoid muscle ventricular zone Top expressed in Gonadal ridge tail of embryo somite genital tubercle mandibular prominence epiblast endothelial cell of lymphatic vessel primitive streak maxillary prominence ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase activity Cellular component nucleoplasm cytosol anaphase-promoting complex nucleus Biological process cell cycle anaphase-promoting complex-dependent catabolic process protein ubiquitination protein K11-linked ubiquitination cell division metaphase regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64682 17222 Ensembl ENSG00000153107 ENSMUSG00000014355 UniProt Q9H1A4 P53995 RefSeq (mRNA) NM_022662 NM_008569 RefSeq (protein) NP_073153 NP_032595 Location (UCSC) Chr 2: 111.61 – 111.88 Mb Chr 2: 128.45 – 128.53 Mb PubMed search [3] [4]
Wikidata
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ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).^[6]