ANP32D

Acidic leucine-rich nuclear phosphoprotein 32 family member D is a protein that in humans is encoded by the ANP32D gene.^[3][4][5]

AliasesANP32D, PP32R2, acidic nuclear phosphoprotein 32 family member D

External IDsOMIM: 606878; GeneCards: ANP32D; OMA:ANP32D - orthologs

Chr.Chromosome 12 (human)^[1]

End48,473,622 bp^[1]

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ANP32D
Identifiers
Aliases	ANP32D, PP32R2, acidic nuclear phosphoprotein 32 family member D
External IDs	OMIM: 606878; GeneCards: ANP32D; OMA:ANP32D - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.11 Start 48,472,559 bp[1] End 48,473,622 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve embryo ganglionic eminence urinary bladder left adrenal gland adrenal cortex left adrenal cortex right adrenal cortex muscle of thigh sigmoid colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding Cellular component nucleus perinuclear region of cytoplasm Biological process nucleosome assembly nucleocytoplasmic transport regulation of apoptotic process histone exchange Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23519 n/a Ensembl ENSG00000139223 n/a UniProt O95626 n/a RefSeq (mRNA) NM_012404 n/a RefSeq (protein) NP_036536 n/a Location (UCSC) Chr 12: 48.47 – 48.47 Mb n/a PubMed search [2] n/a
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Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns.^[5]