ANXA8L2

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesANXA8L1, ANXA8, ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1, annexin A8 like 1

External IDsMGI: 1201374; HomoloGene: 20393; GeneCards: ANXA8L1; OMA:ANXA8L1 - orthologs

Chr.Chromosome 10 (human)^[1]

Quick facts ANXA8L1, Available structures ...

ANXA8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W3W,%%s1W45, 1W3W
Identifiers
Aliases	ANXA8L1, ANXA8, ANXA8L2, VAC-beta, bA145E20.2, annexin A8-like 1, annexin A8 like 1
External IDs	MGI: 1201374; HomoloGene: 20393; GeneCards: ANXA8L1; OMA:ANXA8L1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.22 Start 46,375,627 bp[1] End 46,391,784 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 20.8 cM Start 33,807,938 bp[2] End 33,822,528 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg mucosa of esophagus placenta right lung vagina olfactory zone of nasal mucosa upper lobe of left lung minor salivary glands testicle Top expressed in skin of external ear corneal stroma lip conjunctival fornix ankle ankle joint skin of back skin of abdomen decidua esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium-dependent phospholipid binding metal ion binding calcium ion binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding actin filament binding Cellular component extracellular exosome intracellular anatomical structure cytosol plasma membrane late endosome membrane collagen-containing extracellular matrix Biological process endosome organization endosomal transport negative regulation of serine-type endopeptidase activity negative regulation of phospholipase A2 activity hemostasis blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 728113 11752 Ensembl ENSG00000264230 ENSMUSG00000021950 UniProt Q5VT79 P13928 O35640 RefSeq (mRNA) NM_001039801 NM_001098845 NM_001278923 NM_001278924 NM_001630 NM_001281845 NM_013473 RefSeq (protein) NP_001092315 NP_001265852 NP_001265853 NP_001035173 NP_001258631 NP_001258632 NP_001268774 NP_038501 Location (UCSC) Chr 10: 46.38 – 46.39 Mb Chr 14: 33.81 – 33.82 Mb PubMed search [3] [4]
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This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.^[5]