APBA2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.[5][6]
| APBA2 | |||||||||||||||||||||||||||||||
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| Aliases | APBA2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L, amyloid beta precursor protein binding family A member 2 | ||||||||||||||||||||||||||||||
| External IDs | OMIM: 602712; MGI: 1261791; HomoloGene: 4021; GeneCards: APBA2; OMA:APBA2 - orthologs | ||||||||||||||||||||||||||||||
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Structure
This protein has phosphotyrosine-binding domain (PTB domain or PID) in the middle and two PDZ domains at C-terminal.
Function
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.[6]
