NECAB3

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.^[5][6]

AliasesNECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3

External IDsOMIM: 612478; MGI: 1861721; HomoloGene: 10992; GeneCards: NECAB3; OMA:NECAB3 - orthologs

Chr.Chromosome 20 (human)^[1]

End33,674,463 bp^[1]

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NECAB3
Identifiers
Aliases	NECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDs	OMIM: 612478; MGI: 1861721; HomoloGene: 10992; GeneCards: NECAB3; OMA:NECAB3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 33,657,087 bp[1] End 33,674,463 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,386,319 bp[2] End 154,400,810 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex left ovary right ovary muscle of thigh apex of heart gastric mucosa gastrocnemius muscle body of stomach right lobe of thyroid gland Top expressed in habenula superior frontal gyrus primary visual cortex spermatid dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion embryo prefrontal cortex anterior horn of spinal cord cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding Cellular component nucleus cytoplasm endoplasmic reticulum membrane endoplasmic reticulum Golgi cis cisterna Golgi apparatus Biological process protein secretion protein metabolic process regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63941 56846 Ensembl ENSG00000125967 ENSMUSG00000027489 UniProt Q96P71 Q9D6J4 RefSeq (mRNA) NM_031231 NM_031232 NM_021546 NM_001379147 NM_001379148 NM_001379149 RefSeq (protein) NP_112508 NP_112509 NP_067521 NP_001366076 NP_001366077 NP_001366078 Location (UCSC) Chr 20: 33.66 – 33.67 Mb Chr 2: 154.39 – 154.4 Mb PubMed search [3] [4]
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The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.^[6]