APBB2

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesAPBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2

External IDsOMIM: 602710; MGI: 108405; HomoloGene: 32079; GeneCards: APBB2; OMA:APBB2 - orthologs

Chr.Chromosome 4 (human)^[1]

Quick facts Available structures, PDB ...

APBB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1
Identifiers
Aliases	APBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
External IDs	OMIM: 602710; MGI: 108405; HomoloGene: 32079; GeneCards: APBB2; OMA:APBB2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14-p13 Start 40,810,027 bp[1] End 41,216,714 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.1 Start 66,456,046 bp[2] End 66,776,127 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon sural nerve dorsal motor nucleus of vagus nerve inferior olivary nucleus tendon of biceps brachii internal globus pallidus ventricular zone corpus callosum tibia Top expressed in genital tubercle lateral geniculate nucleus renal corpuscle medial dorsal nucleus pontine nuclei ankle triceps brachii muscle deep cerebellar nuclei lateral septal nucleus medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription factor binding amyloid-beta binding Cellular component growth cone membrane cytoplasm lamellipodium synapse nucleus Biological process positive regulation of apoptotic process intracellular signal transduction negative regulation of cell growth negative regulation of apoptotic process extracellular matrix organization axon guidance neuron migration regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 323 11787 Ensembl ENSG00000163697 ENSMUSG00000029207 UniProt Q92870 Q9DBR4 RefSeq (mRNA) NM_001166050 NM_001166051 NM_001166052 NM_001166053 NM_001166054 NM_004307 NM_173075 NM_001330656 NM_001330658 NM_001201413 NM_001201414 NM_001201415 NM_001201416 NM_009686 NM_001310626 RefSeq (protein) NP_001159522 NP_001159523 NP_001159524 NP_001159525 NP_001159526 NP_001317585 NP_001317587 NP_004298 NP_775098 NP_001188342 NP_001188343 NP_001188344 NP_001188345 NP_001297555 NP_033816 Location (UCSC) Chr 4: 40.81 – 41.22 Mb Chr 5: 66.46 – 66.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.^[7]