APBB3

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesAPBB3, FE65L2, SRA, amyloid beta precursor protein binding family B member 3

External IDsOMIM: 602711; MGI: 108404; HomoloGene: 21221; GeneCards: APBB3; OMA:APBB3 - orthologs

Chr.Chromosome 5 (human)^[1]

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APBB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DYQ, 2YSC
Identifiers
Aliases	APBB3, FE65L2, SRA, amyloid beta precursor protein binding family B member 3
External IDs	OMIM: 602711; MGI: 108404; HomoloGene: 21221; GeneCards: APBB3; OMA:APBB3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,558,268 bp[1] End 140,564,781 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2 Start 36,804,207 bp[2] End 36,812,419 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum left ovary right ovary right adrenal gland right testis right adrenal cortex left adrenal cortex left testis right lobe of thyroid gland pituitary gland Top expressed in neural layer of retina superior frontal gyrus primary visual cortex facial motor nucleus spermatocyte muscle of thigh dentate gyrus of hippocampal formation granule cell cerebellar cortex lumbar spinal ganglion granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function transcription factor binding amyloid-beta binding protein binding Cellular component nucleus actin cytoskeleton cytosol cytoplasm Biological process regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10307 225372 Ensembl ENSG00000113108 ENSMUSG00000117679 UniProt O95704 Q96DX9 Q8R1C9 RefSeq (mRNA) NM_133176 NM_006051 NM_133172 NM_133173 NM_133174 NM_133175 NM_146085 NM_001357512 RefSeq (protein) NP_006042 NP_573418 NP_573419 NP_573420 NP_006042.3 NP_573418.2 NP_573419.2 NP_573420.2 NP_666197 NP_001344441 Location (UCSC) Chr 5: 140.56 – 140.56 Mb Chr 18: 36.8 – 36.81 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.^[6]