APOM

Apolipoprotein M is an apolipoprotein and member of the lipocalin protein family that in humans is encoded by the APOM gene.^[5][6][7] It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.^[7] It lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide.^[8] The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.

PDBOrtholog search: PDBe RCSB

AliasesAPOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M

External IDsOMIM: 606907; MGI: 1930124; HomoloGene: 10308; GeneCards: APOM; OMA:APOM - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts Available structures, PDB ...

APOM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WEW, 2WEX, 2YG2
Identifiers
Aliases	APOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M
External IDs	OMIM: 606907; MGI: 1930124; HomoloGene: 10308; GeneCards: APOM; OMA:APOM - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,652,416 bp[1] End 31,658,210 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,347,973 bp[2] End 35,351,026 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver human kidney gonad renal cortex testicle left testis right testis olfactory zone of nasal mucosa gastrocnemius muscle bone marrow Top expressed in yolk sac left lobe of liver right kidney human fetus human kidney proximal tubule primitive streak fetal liver hematopoietic progenitor cell abdominal wall blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid transporter activity antioxidant activity phospholipid binding Cellular component discoidal high-density lipoprotein particle integral component of plasma membrane very-low-density lipoprotein particle spherical high-density lipoprotein particle extracellular region low-density lipoprotein particle high-density lipoprotein particle extracellular space Biological process lipoprotein metabolic process lipid transport negative regulation of plasma lipoprotein oxidation response to glucose high-density lipoprotein particle assembly retinoid metabolic process high-density lipoprotein particle remodeling cholesterol efflux cholesterol homeostasis reverse cholesterol transport high-density lipoprotein particle clearance cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55937 55938 Ensembl ENSG00000231974 ENSG00000204444 ENSG00000206409 ENSG00000227567 ENSG00000235754 ENSG00000224290 ENSG00000226215 ENSMUSG00000024391 UniProt O95445 Q9Z1R3 RefSeq (mRNA) NM_001256169 NM_019101 NM_018816 RefSeq (protein) NP_001243098 NP_061974 NP_061286 Location (UCSC) Chr 6: 31.65 – 31.66 Mb Chr 17: 35.35 – 35.35 Mb PubMed search [3] [4]
Wikidata
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