APPL2

APPL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H8S, 5C5B
Identifiers
Aliases	APPL2, DIP13B, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
External IDs	OMIM: 606231; MGI: 2384914; HomoloGene: 10046; GeneCards: APPL2; OMA:APPL2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	105,236,203 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	83,484,602 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; rectum; ; mucosa of transverse colon; ; ventricular zone; ; Achilles tendon; ; stromal cell of endometrium; ; canal of the cervix; ; ectocervix; ; bronchial epithelial cell;
	Top expressed in
	retinal pigment epithelium; ; ciliary body; ; iris; ; cerebellar cortex; ; neural layer of retina; ; parotid gland; ; lobe of cerebellum; ; cerebellar vermis; ; lacrimal gland; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylserine binding; phosphatidylinositol binding; protein homodimerization activity; protein-containing complex binding;
Cellular component	cytoplasm; NuRD complex; endosome; early endosome membrane; endosome membrane; extracellular exosome; membrane; nucleus; ruffle; plasma membrane; cytoplasmic vesicle; vesicle; early phagosome; ruffle membrane; early phagosome membrane; macropinosome; phagocytic vesicle membrane; cell projection; phagocytic vesicle;
Biological process	cell cycle; cell population proliferation; signal transduction; diet induced thermogenesis; transforming growth factor beta receptor signaling pathway; cold acclimation; regulation of fibroblast migration; signaling; adiponectin-activated signaling pathway; regulation of toll-like receptor 4 signaling pathway; cellular response to hepatocyte growth factor stimulus; glucose homeostasis; regulation of innate immune response; negative regulation of fatty acid oxidation; negative regulation of glucose import; negative regulation of neurogenesis; protein homotetramerization; positive regulation of phagocytosis, engulfment; positive regulation of cold-induced thermogenesis; negative regulation of cytokine production involved in inflammatory response; negative regulation of cellular response to insulin stimulus; positive regulation of macropinocytosis; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of neural precursor cell proliferation; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	55198
	216190
	ENSG00000136044
	ENSMUSG00000020263
	Q8NEU8
	Q8K3G9
	NM_001251904; NM_001251905; NM_018171
	NM_145220
	NP_001238833; NP_001238834; NP_060641
	NP_660255
	Wikidata
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