ARHGAP25

ARHGAP25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V89
Identifiers
Aliases	ARHGAP25, HEL-S-308, KAIA0053, Rho GTPase activating protein 25
External IDs	OMIM: 610587; MGI: 2443687; HomoloGene: 45507; GeneCards: ARHGAP25; OMA:ARHGAP25 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	68,826,833 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,510,241 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; lymph node; ; monocyte; ; bone marrow cell; ; appendix; ; periodontal fiber; ; tonsil; ; epithelium of colon;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; spleen; ; thymus; ; bone marrow; ; blood; ; lumbar spinal ganglion; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; middle ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	cytosol; phagocytic cup;
Biological process	positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; phagocytosis, engulfment; actin filament organization; negative regulation of small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9938
	232201
	ENSG00000163219
	ENSMUSG00000030047
	P42331
	Q8BYW1
NM_001007231; NM_001166276; NM_001166277; NM_014882; NM_001364819;
	NM_001364820; NM_001364821
	NM_001037727; NM_001286610; NM_175476
NP_001007232; NP_001159748; NP_001159749; NP_055697; NP_001351748;
	NP_001351749; NP_001351750
	NP_001032816; NP_001273539; NP_780685
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene.^[5] The gene is also known as KAIA0053.^[5] ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.^[6]