ARHGAP4

ARHGAP4
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2EPD
Identifiers
Aliases	ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDs	OMIM: 300023; MGI: 2159577; HomoloGene: 20403; GeneCards: ARHGAP4; OMA:ARHGAP4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	153,934,999 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	72,965,476 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; monocyte; ; lymph node; ; blood; ; right lung; ; upper lobe of left lung; ; appendix; ; right hemisphere of cerebellum; ; apex of heart;
	Top expressed in
	granulocyte; ; thymus; ; spleen; ; mesenteric lymph nodes; ; blood; ; tibiofemoral joint; ; bone marrow; ; subcutaneous adipose tissue; ; otic vesicle; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; identical protein binding;
Cellular component	cytosol; Golgi apparatus; growth cone; microtubule; cytoplasm;
Biological process	negative regulation of fibroblast migration; nervous system development; positive regulation of GTPase activity; negative regulation of cell migration; cytoskeleton organization; Rho protein signal transduction; regulation of small GTPase mediated signal transduction; negative regulation of axon extension; signal transduction; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	393
	171207
	ENSG00000089820
	ENSMUSG00000031389
	P98171
	n/a
	NM_001666; NM_001164741
	NM_001162423; NM_001162424; NM_138630
	NP_001158213; NP_001657
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.^[5]^[6] It has been shown to regulate cell motility and axonal outgrowth in vitro.^[7]