ARHGAP5

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP, Rho GTPase activating protein 5
Quick facts Available structures, PDB ...
ARHGAP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP, Rho GTPase activating protein 5
External IDsOMIM: 602680; MGI: 1332637; HomoloGene: 907; GeneCards: ARHGAP5; OMA:ARHGAP5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001030055
NM_001173

NM_009706

RefSeq (protein)

NP_001025226
NP_001164

NP_033836

Location (UCSC)Chr 14: 32.08 – 32.16 MbChr 12: 52.55 – 52.62 Mb
PubMed search[3][4]
Wikidata
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Function

Rho GTPase-activating protein 5 negatively regulates RHO GTPases, a family of proteins that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

ARHGAP5 has been shown to interact with Rnd1,[7] Rnd2,[7] Rnd3[7] and RHOA.[7]

References

Further reading

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