ARHGEF10

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.^[5][6][7]

AliasesARHGEF10, GEF10, SNCV, Rho guanine nucleotide exchange factor 10

External IDsOMIM: 608136; MGI: 2444453; HomoloGene: 22827; GeneCards: ARHGEF10; OMA:ARHGEF10 - orthologs

Chr.Chromosome 8 (human)^[1]

End1,958,641 bp^[1]

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ARHGEF10
Identifiers
Aliases	ARHGEF10, GEF10, SNCV, Rho guanine nucleotide exchange factor 10
External IDs	OMIM: 608136; MGI: 2444453; HomoloGene: 22827; GeneCards: ARHGEF10; OMA:ARHGEF10 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.3 Start 1,823,926 bp[1] End 1,958,641 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 14,911,663 bp[2] End 15,001,085 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right lung corpus callosum apex of heart C1 segment upper lobe of left lung ascending aorta gastric mucosa right testis Descending thoracic aorta Top expressed in sciatic nerve submandibular gland deep cerebellar nuclei ascending aorta globus pallidus lumbar subsegment of spinal cord genital tubercle aortic valve molar optic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinesin binding guanyl-nucleotide exchange factor activity Cellular component cytosol centrosome Biological process mitotic spindle assembly regulation of Rho protein signal transduction positive regulation of stress fiber assembly myelination in peripheral nervous system centrosome duplication activation of GTPase activity actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9639 234094 Ensembl ENSG00000104728 ENSG00000274726 ENSMUSG00000071176 UniProt O15013 Q8C033 RefSeq (mRNA) NM_001308152 NM_001308153 NM_014629 NM_001037736 NM_172751 RefSeq (protein) NP_001295081 NP_001295082 NP_055444 NP_001032825 NP_766339 Location (UCSC) Chr 8: 1.82 – 1.96 Mb Chr 8: 14.91 – 15 Mb PubMed search [3] [4]
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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.^[7]