ARHGEF4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
Quick facts Available structures, PDB ...
ARHGEF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDsOMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_183019
NM_001368773

RefSeq (protein)

NP_898840
NP_001355702

Location (UCSC)Chr 2: 130.84 – 131.05 MbChr 1: 34.68 – 34.81 Mb
PubMed search[3][4]
Wikidata
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Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.[6]

Interactions

ARHGEF4 has been shown to interact with APC.[7]

References

Further reading

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