ARHGEF5

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.^[5][6][7]

AliasesARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5

External IDsOMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs

Chr.Chromosome 7 (human)^[1]

End144,380,632 bp^[1]

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ARHGEF5
Identifiers
Aliases	ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs	OMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q35 Start 144,355,288 bp[1] End 144,380,632 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.1 Start 43,242,516 bp[2] End 43,266,254 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of transverse colon left lobe of thyroid gland right lobe of thyroid gland duodenum minor salivary glands human kidney body of pancreas prostate Top expressed in skin of external ear epithelium of stomach duodenum lip jejunum large intestine colon pyloric antrum mucous cell of stomach left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP binding protein binding lipid binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cell projection plasma membrane nucleoplasm cell junction podosome nucleus cell periphery cytosol Biological process intracellular signal transduction regulation of actin cytoskeleton organization positive regulation of JUN kinase activity regulation of GTPase activity positive regulation of DNA-binding transcription factor activity positive regulation of podosome assembly myeloid dendritic cell chemotaxis positive regulation of GTPase activity positive regulation of protein import regulation of ERK1 and ERK2 cascade regulation of Rho protein signal transduction regulation of cytoskeleton organization actin cytoskeleton organization positive regulation of stress fiber assembly positive regulation of apoptotic process regulation of small GTPase mediated signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7984 54324 Ensembl ENSG00000050327 ENSMUSG00000033542 UniProt Q12774 E9Q7D5 RefSeq (mRNA) NM_001002861 NM_005435 NM_133674 RefSeq (protein) NP_005426 NP_598435 Location (UCSC) Chr 7: 144.36 – 144.38 Mb Chr 6: 43.24 – 43.27 Mb PubMed search [3] [4]
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Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.^[7]