ARL2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesARL2, ARFL2, ADP ribosylation factor like GTPase 2, MRCS1
Quick facts Available structures, PDB ...
ARL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARL2, ARFL2, ADP ribosylation factor like GTPase 2, MRCS1
External IDsOMIM: 601175; MGI: 1928393; HomoloGene: 1260; GeneCards: ARL2; OMA:ARL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001667
NM_001199745

NM_019722

RefSeq (protein)

NP_001186674
NP_001658

NP_062696

Location (UCSC)Chr 11: 65.01 – 65.02 MbChr 19: 6.18 – 6.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

  • The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes.[7]
  • In photoreceptors, ARL2 participates in the trafficking of lipidated membrane-associated proteins.[8]
  • There is an evidence that increased activity of ARL2 protein is strongly correlated with increased mitochondria fusion, while loss of ARL2 activity results in a decreased rate of fusion.[9]

Interactions

References

Further reading

Related Articles

Wikiwand AI