ARMCX3

Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene.^[5][6][7][8]

AliasesARMCX3, ALEX3, GASP6, dJ545K15.2, armadillo repeat containing, X-linked 3, armadillo repeat containing X-linked 3

External IDsOMIM: 300364; MGI: 1918953; HomoloGene: 9588; GeneCards: ARMCX3; OMA:ARMCX3 - orthologs

Chr.X chromosome (human)^[1]

End101,627,843 bp^[1]

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ARMCX3
Identifiers
Aliases	ARMCX3, ALEX3, GASP6, dJ545K15.2, armadillo repeat containing, X-linked 3, armadillo repeat containing X-linked 3
External IDs	OMIM: 300364; MGI: 1918953; HomoloGene: 9588; GeneCards: ARMCX3; OMA:ARMCX3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 101,622,797 bp[1] End 101,627,843 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E3 Start 133,657,344 bp[2] End 133,662,204 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta external globus pallidus spinal ganglia pars reticulata corpus epididymis pons cardia superior vestibular nucleus pylorus Top expressed in dentate gyrus of hippocampal formation granule cell ovary hippocampus proper neural tube pancreas primary visual cortex superior frontal gyrus islet of Langerhans cerebellar cortex mesencephalon More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 51566 71703 Ensembl ENSG00000102401 ENSMUSG00000049047 UniProt Q9UH62 Q8BHS6 RefSeq (mRNA) NM_016607 NM_177947 NM_177948 NM_027870 NM_001358520 NM_001358521 RefSeq (protein) NP_057691 NP_808816 NP_808817 NP_057691.1 NP_808816.1 NP_808817.1 NP_082146 NP_001345449 NP_001345450 Location (UCSC) Chr X: 101.62 – 101.63 Mb Chr X: 133.66 – 133.66 Mb PubMed search [3] [4]
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This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene.^[8]