ARPP-21

ARPP21
Identifiers
Aliases	ARPP21, ARPP-21, R3HDM3, RCS, TARPP, cAMP regulated phosphoprotein 21kDa, cAMP regulated phosphoprotein 21
External IDs	OMIM: 605488; MGI: 107562; HomoloGene: 32306; GeneCards: ARPP21; OMA:ARPP21 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	35,794,496 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	112,235,938 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; middle temporal gyrus; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; primary visual cortex; ; Brodmann area 23; ; right frontal lobe;
	Top expressed in
	olfactory tubercle; ; globus pallidus; ; piriform cortex; ; nucleus accumbens; ; superior frontal gyrus; ; temporal lobe; ; cingulate gyrus; ; visual cortex; ; primary motor cortex; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	calmodulin binding; nucleic acid binding; molecular function;
Cellular component	cytoplasm; cellular component;
Biological process	cellular response to heat; biological process;
	Sources:Amigo / QuickGO
Orthologs
	10777
	74100
	ENSG00000172995
	ENSMUSG00000032503
	Q9UBL0
	Q9DCB4
NM_001025068; NM_001025069; NM_001267616; NM_001267617; NM_001267618;
	NM_001267619; NM_016300; NM_198399
NM_001177615; NM_001177616; NM_001177617; NM_001177618; NM_001177619;
	NM_001177620; NM_001177623; NM_028755; NM_033264
NP_001020239; NP_001020240; NP_001254545; NP_001254546; NP_001254547;
	NP_001254548; NP_057384; NP_938409
NP_001171086; NP_001171087; NP_001171088; NP_001171089; NP_001171090;
	NP_001171091; NP_001171094; NP_083031; NP_150289; NP_001348929; NP_001348930; NP_001348931; NP_001348932; NP_001348933; NP_001348934; NP_001348935; NP_001348936; NP_001348937; NP_001348938; NP_001348939; NP_001348940; NP_001348941; NP_001348942; NP_001348943; NP_001348944; NP_001348945; NP_001348946; NP_001348947; NP_001348948; NP_001348949; NP_001348950; NP_001348951; NP_001348952; NP_001348953; NP_001348954; NP_001348955; NP_001348956; NP_001348957; NP_001348958; NP_001348959; NP_001348960; NP_001348961; NP_001348962; NP_001348963; NP_001348964; NP_001348965; NP_001348966; NP_001348967; NP_001348968; NP_001348969; NP_001348970
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-regulated phosphoprotein, 21 kDa, also known as ARPP-21, is a human gene.^[5] Research published in March 2026 identified ARPP-21 as one of the genes contributing to overall risk of developing amyotrophic lateral sclerosis (ALS).^[6] A new high-impact ARPP-21 variant was identified (p.P747L), and variant p.P563L was confirmed to be associated with more aggressive disease progression.^[7]