ASB2

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans.^[5]

AliasesASB2, ASB-2, ankyrin repeat and SOCS box containing 2

External IDsOMIM: 605759; MGI: 1929743; HomoloGene: 69202; GeneCards: ASB2; OMA:ASB2 - orthologs

Chr.Chromosome 14 (human)^[1]

End93,976,739 bp^[1]

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ASB2
Identifiers
Aliases	ASB2, ASB-2, ankyrin repeat and SOCS box containing 2
External IDs	OMIM: 605759; MGI: 1929743; HomoloGene: 69202; GeneCards: ASB2; OMA:ASB2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 93,934,166 bp[1] End 93,976,739 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 E|12 52.9 cM Start 103,287,401 bp[2] End 103,322,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skeletal muscle tissue gastrocnemius muscle muscle of thigh apex of heart left ventricle smooth muscle tissue muscle layer of sigmoid colon right auricle of heart left uterine tube right coronary artery Top expressed in knee joint muscle of thigh vastus lateralis muscle triceps brachii muscle temporal muscle myocardium of ventricle tibialis anterior muscle sternocleidomastoid muscle digastric muscle skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase activity Cellular component Cul5-RING ubiquitin ligase complex cytosol ubiquitin ligase complex Biological process skeletal muscle cell differentiation myoblast differentiation intracellular signal transduction protein polyubiquitination signal transduction post-translational protein modification protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51676 65256 Ensembl ENSG00000100628 ENSG00000278693 ENSMUSG00000021200 UniProt Q96Q27 Q8K0L0 RefSeq (mRNA) NM_001202429 NM_016150 NM_023049 NM_001374764 RefSeq (protein) NP_001189358 NP_057234 NP_075536 NP_001361693 Location (UCSC) Chr 14: 93.93 – 93.98 Mb Chr 12: 103.29 – 103.32 Mb PubMed search [3] [4]
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The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.^[5]