ASB3

Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene.^[5][6]

AliasesASB3, ASB-3, ankyrin repeat and SOCS box containing 3

External IDsOMIM: 605760; MGI: 1929749; HomoloGene: 9391; GeneCards: ASB3; OMA:ASB3 - orthologs

Chr.Chromosome 2 (human)^[1]

End53,860,160 bp^[1]

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ASB3
Identifiers
Aliases	ASB3, ASB-3, ankyrin repeat and SOCS box containing 3
External IDs	OMIM: 605760; MGI: 1929749; HomoloGene: 9391; GeneCards: ASB3; OMA:ASB3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.2 Start 53,532,672 bp[1] End 53,860,160 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A4|11 18.19 cM Start 30,835,416 bp[2] End 31,052,704 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone ganglionic eminence middle temporal gyrus endothelial cell tibia corpus callosum entorhinal cortex testicle postcentral gyrus Top expressed in spermatocyte endocardial cushion medial ganglionic eminence granulocyte spermatid ventricular zone cumulus cell otic placode lumbar spinal ganglion genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding ubiquitin protein ligase binding ubiquitin-protein transferase activity Cellular component cytoplasm nucleus ubiquitin ligase complex cytosol Biological process protein ubiquitination intracellular signal transduction post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51130 65257 Ensembl ENSG00000115239 ENSMUSG00000020305 UniProt Q9Y575 Q9WV72 RefSeq (mRNA) NM_145863 NM_001201965 NM_016115 NM_023906 RefSeq (protein) NP_001157637 NP_076395 Location (UCSC) Chr 2: 53.53 – 53.86 Mb Chr 11: 30.84 – 31.05 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.^[6]